Day 1 Santiago
Set within a circle of snow-capped mountains, Santiago is vibrant, artistic and gourmet - and the gateway to adventures in the snow, sea or desert.
Days 2-3 Mendoza
Famed for its wine and raft of adventure activities, Mendoza is a lovely city to get lost in with its wide streets, excellent eateries and gorgeous plazas.
Days 4-7 Estancia Stay
Set in the picturesque landscape around Rio Ceballos, this traditional Argentine estancia offers the opportunity to live like a gaucho with horse-riding, hiking and sampling an asado (barbecue).
Day 8 Quilmes
The ruined citadel of the Quilmes - a local people displaced in the 17th century by the Spanish - is a fascinating site located in Argentina's Calchaqui Valley.
Day 9 Cafayate
Vineyards, wineries and artisans dominate the picturesque town of Cafayate and its surrounds, the perfect place to sample some world-class wine, food and scenery.
Days 10-11 Salta
With its well-preserved colonial buildings, candle-lit cafes, fine museums and surrounding natural beauty, Salta is one of Argentina's most charming cities.
Days 12-13 San Pedro de Atacama
Gorgeous desert landscapes, atmospheric, whitewashed adobe houses and a lively town centre has made San Pedro de Atacama one of Chile's most popular travel destinations.
Day 14 Bolivian Altiplano
A true wilderness featuring volcanoes, salt pans and colourful lakes, the Bolivian Altiplano stretches out from Lake Titicaca to the borders of Argentina and Chile.
Days 15-17 Uyuni/Salar de Uyuni
Popular due to its proximity to the Salar de Uyuni, the town of Uyuni is small and charming, and feels very remote, especially at the photogenic train cemetery.
The world's largest salt flat, the Salar de Uyuni, is a spectacular sight - whether reflecting like a mirror in the wet or cracking during the dry.
Days 18-19 Potosi
The loveliness of Potosi - one of the highest and more fascinating cities in the world - is mirrored by the harshness of its mines and mining history.
Days 20-21 La Paz
Built in a canyon, the unique and bewtiching city of La Paz is filled with steep, cobbled streets, fascinating markets, evident tradition and captivating sights.